Description

2-(4-Bromo-2-Fluoro-5-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity, synthetically valuable boronic ester derivative, serving as a critical building block in modern organic synthesis. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone technology for constructing complex molecules. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality intermediates for drug discovery and specialty chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex biaryl or heterobiaryl structures.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific halogenated aromatic motifs.
• Material Science Research: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where precise molecular architecture is crucial.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling to introduce the substituted phenylboronate moiety into target molecules.
• Chemical Biology & Medicinal Chemistry: Serves as a versatile building block for creating molecular probes, imaging agents, and compound libraries for high-throughput screening.
• Custom Synthesis & Contract Manufacturing: A vital raw material for fine chemical manufacturers offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	2-(4-Bromo-2-Fluoro-5-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2096334-00-6
Molecular Formula	C13H17BBrFO2
Molecular Weight	315.99 g/mol
Synonyms	4-Bromo-2-fluoro-5-methylbenzeneboronic acid pinacol ester; (4-Bromo-2-fluoro-5-methylphenyl)boronic acid pinacol ester; 2-Fluoro-4-bromo-5-methylphenylboronic acid pinacol ester; 4-Bromo-2-fluoro-5-methylphenylboronic acid neopentyl glycol ester (common alternative); Pinacol (4-Bromo-2-fluoro-5-methylphenyl)boronate; 2096334-00-6; BRN 9081023
EINECS	Contact for details

Quality Control

Every batch of 2-(4-Bromo-2-Fluoro-5-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, NMR, and GC, is performed to verify identity, purity, and impurity profiles. Certificates of Analysis (COA) with full batch traceability are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.