Description

3-Bromo-5-Carboxyphenylboronic Acid, Pinacol Ester is a high-value, multi-functional boronic ester derivative designed for advanced organic synthesis. This compound is a critical building block in modern medicinal chemistry and materials science, offering a protected boronic acid group and a carboxylic acid handle for sequential functionalization. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel active ingredients and functional materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key electrophilic or nucleophilic partner for constructing biaryl and heterobiaryl scaffolds central to drug discovery.
• Pharmaceutical Intermediate: Used in the synthesis of complex molecules for oncology, CNS, and antiviral research programs.
• Agrochemical Development: Employed in creating novel active ingredients with specific biological activity.
• Ligand Synthesis for Catalysis: The boronic ester and carboxylic acid groups allow for the creation of sophisticated chelating ligands.
• Materials Science & OLEDs: Acts as a precursor for organic electronic materials and metal-organic frameworks (MOFs).
• Peptide Modification & Bioconjugation: The carboxylic acid functionality enables coupling to amines for labeling and probe development.

Basic Information

Product Name	3-Bromo-5-Carboxyphenylboronic Acid, Pinacol Ester
CAS No.	2096333-90-1
Molecular Formula	C14H18BBrO4
Molecular Weight	341.01 g/mol
Synonyms	(3-Bromo-5-carboxyphenyl)boronic acid pinacol ester; 5-Bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid; 3-Bromo-5-carboxybenzeneboronic acid pinacol ester; 2-(3-Bromo-5-carboxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (3-bromo-5-carboxyphenyl)boronate; 2096333-90-1; Boronic acid, B-(3-bromo-5-carboxyphenyl)-, 1,1-dimethylethyl ester (9CI)
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-5-Carboxyphenylboronic Acid, Pinacol Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area. For long-term storage, consider storing under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.