Description

1-(4-Chloro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Pyrrolidine is a high-purity, advanced pharmaceutical intermediate featuring a key boronic ester functional group. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of new active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) targets.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, especially those requiring complex biaryl linkages.
• Suzuki-Miyaura Cross-Coupling Reagent: Serves as a versatile organoboron partner for palladium-catalyzed carbon-carbon bond formation with aryl halides.
• Medicinal Chemistry Research: Enables the rapid exploration of structure-activity relationships (SAR) in drug discovery programs by providing a handle for late-stage functionalization.
• Agrochemical Synthesis: Used in the research and development of new herbicides and fungicides that incorporate advanced aromatic systems.
• Material Science Precursor: Potential intermediate in the development of organic electronic materials, such as polymers for OLEDs, due to its aromatic and coupling capabilities.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the pharmaceutical and chemical industries with custom synthesis and scale-up.

Basic Information

Product Name	1-(4-Chloro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Pyrrolidine
CAS No.	2096333-77-4
Molecular Formula	C17H25BClNO2
Molecular Weight	321.65 g/mol
Synonyms	1-[(4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methyl]pyrrolidine; 4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl pyrrolidine; (4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)(pyrrolidin-1-yl)methane; 1-((4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl))pyrrolidine; Boronic ester pyrrolidine derivative CAS 2096333-77-4
EINECS	Contact for details

Quality Control

Our 1-(4-Chloro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature: 2-8°C (refrigerated) for optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.