Description

1-(2-Methylpropyl)-3,5-Bis(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrazole is a high-purity, advanced pharmaceutical intermediate featuring a unique pyrazole core symmetrically functionalized with pinacol boronate ester groups. This compound is specifically engineered for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl and heterobiaryl scaffolds. It is an essential building block for researchers and manufacturers in pharmaceutical R&D and agrochemical synthesis who require reliable, high-quality boronic ester reagents to accelerate drug discovery and development pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting a wide range of therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boron reagent for forming carbon-carbon bonds between aromatic and heteroaromatic rings under mild conditions.
• Medicinal Chemistry & Drug Discovery: Used in library synthesis for high-throughput screening and structure-activity relationship (SAR) studies to identify novel drug candidates.
• Agrochemical Synthesis: Employed in the development of new herbicides, fungicides, and insecticides with complex heterocyclic structures.
• Material Science Research: A building block for creating organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug development and scale-up activities.

Basic Information

Item	Details
Product Name	1-(2-Methylpropyl)-3,5-Bis(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrazole
CAS No.	2096332-54-4
Molecular Formula	C22H40B2N2O4
Molecular Weight	418.18 g/mol
Synonyms	3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-isobutylpyrazole; 1-Isobutyl-3,5-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-(2-Methylpropyl)-3,5-di(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole; 3,5-Di(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-isobutyl-1H-pyrazole; Pyrazole Boronic Ester Pinacol; Isobutyl Pyrazole Bis-Boronate
EINECS	Contact for details

Quality Control

Our 1-(2-Methylpropyl)-3,5-Bis(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrazole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including NMR (1H, 13C, 11B), HPLC, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Under these conditions, the product is stable for extended periods. The container must be kept tightly sealed in a dry environment to prevent potential moisture ingress, which could affect the boronate ester functionality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.