Description

1-Boc-Oxindole-5-Boronic Acid, Pinacol Ester is a high-purity, protected boronic ester derivative, a critical building block in modern synthetic organic chemistry. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, enabling the efficient and selective formation of carbon-carbon bonds. It is an essential intermediate for pharmaceutical R&D and fine chemical synthesis, particularly in constructing complex heterocyclic scaffolds for drug discovery programs targeting CNS disorders, oncology, and inflammation.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of oxindole-based active pharmaceutical ingredients (APIs) and investigational new drugs.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for palladium-catalyzed coupling with aryl/heteroaryl halides, enabling library synthesis.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and structure-activity relationship (SAR) studies to develop novel therapeutic agents.
• Fine Chemical Synthesis: Intermediate in the production of advanced agrochemicals, dyes, and functional materials.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	1-Boc-Oxindole-5-Boronic Acid, Pinacol Ester
CAS No.	2096332-45-3
Molecular Formula	C19H26BNO5
Molecular Weight	359.23 g/mol
Synonyms	1-Boc-5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-oxoindoline-1-carboxylic acid tert-butyl ester; tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-oxoindoline-1-carboxylate; 1-(tert-Butoxycarbonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one; 5-Borono-1-Boc-oxindole pinacol ester; 1-Boc-5-Bpin-oxindole
EINECS	Contact for details

Quality Control

Our 1-Boc-Oxindole-5-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. Under these conditions, the product is stable for extended periods. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.