Description

1-{[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}Pyrrolidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling key carbon-carbon bond-forming reactions, such as the Suzuki-Miyaura cross-coupling, which are fundamental in modern medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules for drug discovery and development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those requiring boronic acid/ester chemistry.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a crucial coupling partner for constructing biaryl and other conjugated systems central to many therapeutic agents.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new molecular entities.
• Organic Synthesis Research: Employed in academic and industrial R&D for constructing complex, boron-containing organic frameworks.
• Precursor for PROTACs & Bifunctional Molecules: Acts as a synthetic handle for creating proteolysis-targeting chimeras and other advanced therapeutic modalities.
• Material Science Research: Potential use in the development of organic electronic materials and polymers where precise boron integration is required.

Basic Information

Item	Details
Product Name	1-{[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}Pyrrolidine Hydrochloride
CAS No.	2096332-19-1
Molecular Formula	C17H27BClNO2
Molecular Weight	323.66 g/mol
Synonyms	1-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)pyrrolidine hydrochloride; 4-((Pyrrolidin-1-yl)methyl)phenylboronic acid pinacol ester hydrochloride; 1-[[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]pyrrolidine HCl; (4-((Pyrrolidin-1-yl)methyl)phenyl)boronic acid pinacol ester hydrochloride; CAS 2096332-19-1
EINECS	Contact for details

Quality Control

Our 1-{[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting full specifications are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.