Description

{[2-Fluoro-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}Dimethylamine Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a boronic ester pinacol group, making it a crucial building block for Suzuki-Miyaura cross-coupling reactions. This compound is essential for the efficient synthesis of complex, fluorinated biaryl structures, which are highly sought after in modern drug discovery programs. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated biphenyl or heterobiaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Serves as a stable, air-tolerant boronic ester partner for palladium-catalyzed carbon-carbon bond formation, enabling the construction of complex molecular architectures.
• Medicinal Chemistry Research: Used in high-throughput screening and lead optimization to rapidly generate libraries of fluorinated compounds for biological evaluation.
• Agrochemical Synthesis: Employed in the development of new herbicides, fungicides, and insecticides where the fluorinated biaryl scaffold can enhance stability and bioactivity.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials, such as fluorinated polymers or small molecules for OLEDs, where precise structural control is required.
• Process Chemistry & Scale-Up: Suitable for kilogram-scale production under GMP-like conditions for late-stage clinical candidate and commercial API manufacturing.

Basic Information

Product Name	{[2-Fluoro-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}Dimethylamine Hydrochloride
CAS No.	2096332-16-8
Molecular Formula	C15H24BClFNO2
Molecular Weight	315.62 g/mol
Synonyms	(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)dimethylamine hydrochloride; N,N-Dimethyl-1-[2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanamine hydrochloride; 2-Fluoro-4-(N,N-dimethylaminomethyl)phenylboronic acid pinacol ester hydrochloride; 4-(Dimethylaminomethyl)-3-fluorophenylboronic acid pinacol ester hydrochloride; Boronic acid, B-[4-[(dimethylamino)methyl]-3-fluorophenyl]-, pinacol ester, hydrochloride; 2096332-16-8; Fluorinated aminomethyl phenylboronate ester HCl salt
EINECS	Contact for details

Quality Control

Our {[2-Fluoro-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}Dimethylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, low-humidity environment to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.