Description

1-(3-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Pyrrolidine is a high-purity, advanced pharmaceutical intermediate featuring a pyrrolidine moiety and a protected boronic ester functional group. This compound is critically important as a key building block in modern cross-coupling reactions, such as the Suzuki-Miyaura reaction, enabling the efficient synthesis of complex bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of new therapeutic agents, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs) for oncology, neurology, and antiviral therapies.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boron-containing coupling partner for constructing biaryl and heterobiaryl scaffolds central to medicinal chemistry.
• Drug Discovery & Medicinal Chemistry: Used in high-throughput screening and lead optimization campaigns to explore novel chemical space and structure-activity relationships (SAR).
• Chemical Biology Probe Development: Employed in the creation of molecular probes for target identification and validation in biological systems.
• Agrochemical Research: Acts as a building block for developing new crop protection agents and pesticides with novel modes of action.
• Material Science: Potential monomer or precursor for functional polymers and organic electronic materials.

Basic Information

Product Name	1-(3-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Pyrrolidine
CAS No.	2096331-84-7
Molecular Formula	C16H23BClNO2
Molecular Weight	307.62 g/mol
Synonyms	1-[3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrrolidine; 3-Chloro-5-(pyrrolidin-1-yl)phenylboronic acid pinacol ester; 1-(3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrrolidine; (3-Chloro-5-(pyrrolidin-1-yl)phenyl)boronic acid pinacol ester; 2096331-84-7; 1-(3-Chloro-5-(pinacolatoboryl)phenyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our 1-(3-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.