Description

6-Borono-5-Fluoro-1-Methyl-1H-Indazole is a high-value, multi-functional heterocyclic building block featuring a boronic acid group and a fluorine substituent. This compound is critical for modern drug discovery programs, particularly in the development of targeted covalent inhibitors and proteolysis-targeting chimeras (PROTACs). It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel kinase inhibitors and other biologically active molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of covalent kinase inhibitors, leveraging the boronic acid group for Suzuki-Miyaura cross-coupling reactions.
• PROTACs Development: Serves as a versatile linker or warhead component in the design and construction of proteolysis-targeting chimeras for targeted protein degradation.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization for oncology and inflammatory disease targets.
• Bioconjugation: The boronic acid functionality allows for selective conjugation with diols, enabling applications in chemical biology and diagnostic probe development.
• Material Science: Potential use as a monomer or functional additive in the synthesis of advanced polymeric materials with specific electronic or binding properties.

Basic Information

Product Name	6-Borono-5-Fluoro-1-Methyl-1H-Indazole
CAS No.	2096331-06-3
Molecular Formula	C8H8BFN2O2
Molecular Weight	193.97 g/mol
Synonyms	5-Fluoro-1-methyl-1H-indazole-6-boronic acid; 6-Borono-5-fluoro-1-methylindazole; 1-Methyl-5-fluoro-1H-indazole-6-boronic acid; (5-Fluoro-1-methyl-1H-indazol-6-yl)boronic acid; B-(5-Fluoro-1-methyl-1H-indazol-6-yl)boronic acid; 2096331-06-3; 6-Borono-5-fluoro-1-methyl-1H-indazole pinacol ester (common derivative).
EINECS	Contact for details

Quality Control

Our 6-Borono-5-Fluoro-1-Methyl-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, 1H/13C/19F/11B NMR for structural confirmation, and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and easily oxidized nature, this material should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place at 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.