Description

4-{[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}Thiomorpholine is a high-purity, advanced pharmaceutical intermediate featuring a unique boronic ester-protected phenylthiomorpholine structure. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry for constructing complex biaryl scaffolds. It is primarily utilized by research and development teams in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling Reagent: Serves as a stable, air- and moisture-tolerant boronic ester partner for palladium-catalyzed carbon-carbon bond formation.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science & OLED Development: Employed in the creation of organic electronic materials, including charge-transport layers and emissive materials for displays.
• Chemical Biology & Probe Synthesis: Facilitates the labeling and modification of biomolecules for diagnostic and research applications.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries to identify new biological hits.

Basic Information

Product Name	4-{[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}Thiomorpholine
CAS No.	2096330-90-2
Molecular Formula	C17H26BNO2S
Molecular Weight	319.27 g/mol
Synonyms	4-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)thiomorpholine; 2-[4-(Thiomorpholin-4-ylmethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)thiomorpholine; (4-(Thiomorpholinomethyl)phenyl)boronic acid pinacol ester; Pinacol [4-(thiomorpholin-4-ylmethyl)phenyl]boronate; 4,4,5,5-Tetramethyl-2-[4-(thiomorpholin-4-ylmethyl)phenyl]-1,3,2-dioxaborolane; 2096330-90-2
EINECS	Contact for details

Quality Control

Our 4-{[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Methyl}Thiomorpholine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.