Description

Benzoic Acid, 4-Fluoro-3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Methyl Ester is a high-value, multi-functional organic building block that combines a benzoate ester core with a pinacol boronate ester group. This compound matters for its critical role in modern synthetic chemistry, particularly in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex fluorinated and substituted aromatic systems. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing fluorinated drug candidates, including kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific fluorinated aromatic motifs for enhanced activity and stability.
• Material Science Research: Serves as a precursor for creating advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where the boronate ester enables precise molecular assembly.
• Chemical Biology & Proteomics: Employed in the synthesis of chemical probes and affinity tags for studying protein function and biological pathways.
• Cross-Coupling Reactions: Primarily designed as a versatile coupling partner in palladium-catalyzed Suzuki-Miyaura reactions to form biaryl and heterobiaryl structures.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds at various scales, from research to pilot plant.

Basic Information

Product Name	Benzoic Acid, 4-Fluoro-3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Methyl Ester
CAS No.	2096330-13-9
Molecular Formula	C15H20BFO4
Molecular Weight	294.13 g/mol
Synonyms	Methyl 4-Fluoro-3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; 4-Fluoro-3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic Acid Methyl Ester; 2-Boronic acid, 4-fluoro-3-methyl-5-methoxycarbonylbenzeneboronic acid pinacol ester; (4-Fluoro-3-methyl-5-methoxycarbonylphenyl)boronic acid pinacol ester; 2096330-13-9; 4-Fluoro-3-methyl-5-(pinacolatoboryl)benzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our Benzoic Acid, 4-Fluoro-3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C for long-term stability, although the product is stable at room temperature for short periods. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation of the boronate ester functionality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.