Description

4-(n-Cbz-n-Ethylamino)Phenylboronic Acid, Pinacol Ester is a sophisticated, protected boronic ester derivative designed for advanced synthetic chemistry. This compound is a critical building block in modern pharmaceutical research and development, particularly for the construction of complex molecules via Suzuki-Miyaura cross-coupling reactions. It is essential for medicinal chemists and process R&D teams in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, reliable intermediates for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key protected precursor in the synthesis of novel drug candidates, especially those containing biaryl motifs common in kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, air- and moisture-tolerant boronate reagent for palladium-catalyzed carbon-carbon bond formation with aryl/heteroaryl halides.
• Medicinal Chemistry & SAR Studies: Enables the efficient exploration of structure-activity relationships by allowing the modular introduction of functionalized phenyl groups into molecular scaffolds.
• Peptide & Protein Conjugation: The Cbz (carboxybenzyl) protecting group allows for orthogonal deprotection strategies, making it useful in bioconjugation chemistry.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific aryl-amino-boronate structures.
• Materials Science: Acts as a monomer or functionalization agent in the synthesis of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Biology Probes: Facilitates the creation of tagged molecules for studying biological pathways and target engagement.

Basic Information

Product Name	4-(n-Cbz-n-Ethylamino)Phenylboronic Acid, Pinacol Ester
CAS No.	2096330-01-5
Molecular Formula	C22H28BNO4
Molecular Weight	381.28 g/mol
Synonyms	[4-[[(Benzyloxy)carbonyl](ethyl)amino]phenyl]boronic acid pinacol ester; 4-(N-Cbz-N-Ethylamino)benzeneboronic acid pinacol ester; N-Cbz-N-Ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; 4-[(Benzyloxycarbonyl)(ethyl)amino]phenylboronic acid pinacol ester; CAS 2096330-01-5; Pinacol [4-[[(benzyloxy)carbonyl](ethyl)amino]phenyl]boronate; B-[4-[[(Benzyloxy)carbonyl](ethyl)amino]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 4-(n-Cbz-n-Ethylamino)Phenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our analytical methods, including HPLC, NMR, and MS, are validated to provide reliable data for our global customer base in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong acids and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.