Description

Methyl 3-Chloro-2-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate CAS NO 2096329-94-9 is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is critically important for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the discovery and development of new active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing novel drug candidates, particularly those containing complex, substituted biphenyl or heterobiaryl scaffolds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific halogenated aromatic motifs.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs or organic photovoltaics, where precise molecular architecture is crucial.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and labeled compounds for biochemical assays and diagnostic applications.
• Contract Research & Development (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client projects.
• Academic Research: Used in university and institutional labs for methodological development in synthetic organic chemistry and catalysis studies.

Basic Information

Product Name	Methyl 3-Chloro-2-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate
CAS No.	2096329-94-9
Molecular Formula	C14H17BClFO4
Molecular Weight	314.54 g/mol
Synonyms	3-Chloro-2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid methyl ester; Methyl 3-chloro-2-fluoro-5-(pinacolatoboron)benzoate; 3-Chloro-2-fluoro-5-(pinacolboronato)benzoic acid methyl ester; 2096329-94-9; Benzoic acid, 3-chloro-2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 3-Chloro-2-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate adheres to stringent quality management protocols. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR (1H, 13C, 19F, 11B), and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support compliance with REACH and other global regulatory frameworks as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged manipulations or when opening the primary container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.