Description

(S)-3-Methyl-1-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Butan-1-Amine is a high-purity, chiral amine boronic ester building block essential for modern synthetic chemistry. This compound matters for its role as a key intermediate in the synthesis of complex, biologically active molecules, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing novel compounds via cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of protease inhibitors and other small-molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronate ester reagent for forming carbon-carbon bonds, enabling the introduction of the chiral 3-methylbutylamine moiety into complex molecular architectures.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening libraries and for the structure-activity relationship (SAR) optimization of lead compounds due to its defined stereochemistry.
• Agrochemical Synthesis: Employed in the research and production of chiral pesticides and herbicides where specific stereochemistry is required for efficacy.
• Ligand and Catalyst Development: Acts as a precursor for chiral ligands used in asymmetric catalysis.
• Advanced Material Research: Potential monomer or functionalization agent in the synthesis of specialized polymers and organic electronic materials.

Basic Information

Product Name	(S)-3-Methyl-1-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Butan-1-Amine
CAS No.	2095886-42-1
Molecular Formula	C11H24BNO2
Molecular Weight	213.13 g/mol
Synonyms	(S)-1-Amino-3-methylbutylboronic acid pinacol ester; (S)-3-Methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butan-1-amine; (S)-1-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methylbutan-1-amine; (S)-3-Methyl-1-(pinacolatoboryl)butan-1-amine; (S)-Leucine-derived aminoboronic acid pinacol ester; (S)-1-Amino-3-methylbutylboronate pinacol ester; B-(1-Amino-3-methylbutyl)boronic acid pinacol ester (S-isomer)
EINECS	Contact for details

Quality Control

Our (S)-3-Methyl-1-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Butan-1-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity suitable for sensitive applications like pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.