Description

2-Hydroxy-3-Methylphenylboronic Acid Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a key intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. It is primarily utilized by pharmaceutical R&D teams, agrochemical manufacturers, and advanced material scientists for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing ortho-substituted biphenyl scaffolds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific aryl-aryl linkages.
• Material Science: Employed in the creation of organic electronic materials, such as those for OLEDs and organic photovoltaics, where precise molecular architecture is crucial.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology & Proteomics: Utilized in the synthesis of molecular probes and activity-based protein profiling (ABPP) agents that target specific enzymes.
• Academic & Industrial R&D: A valuable reagent for methodological development in cross-coupling chemistry and exploring new synthetic pathways in laboratory settings.

Basic Information

Product Name	2-Hydroxy-3-Methylphenylboronic Acid Pinacol Ester
CAS No.	2095797-27-4
Molecular Formula	C14H21BO3
Molecular Weight	248.13 g/mol
Synonyms	2-(3-Methyl-2-hydroxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (3-Methyl-2-hydroxyphenyl)boronic acid pinacol ester; 2-Hydroxy-3-methylbenzeneboronic acid pinacol ester; Pinacol (2-hydroxy-3-methylphenyl)boronate; 2-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; B-(3-Methyl-2-hydroxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-3-Methylphenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for demanding synthetic applications. All products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.