Description

4-Bromo-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol is a high-value, multi-functional boronic ester derivative that serves as a critical synthetic intermediate in modern organic chemistry. Its core value proposition lies in enabling efficient cross-coupling reactions, which are fundamental for constructing complex molecular architectures in a controlled and predictable manner. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise building blocks for drug discovery, ligand synthesis, and polymer development.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biaryl or phenolic motifs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the introduction of a bromophenol-boronate moiety can modulate biological activity and selectivity.
• Material Science & OLED Development: Serves as a building block for creating organic semiconductors, liquid crystals, and light-emitting materials for electronic displays and devices.
• Ligand & Catalyst Design: Employed in the synthesis of specialized ligands for transition metal catalysis and organoboron reagents for further functionalization.
• Polymer Chemistry: Acts as a monomer or chain-transfer agent in the production of specialty polymers with tailored properties like thermal stability or specific optical characteristics.
• Chemical Biology & Proteomics: Utilized as a probe or linker in bioconjugation strategies and the development of activity-based protein profiling reagents.

Basic Information

Product Name	4-Bromo-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol
CAS No.	2095797-20-7
Molecular Formula	C12H16BBrO3
Molecular Weight	299.97 g/mol
Synonyms	2-Bromo-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; 4-Bromo-2-(pinacolato)phenol; 4-Bromo-2-pinacolborylphenol; Phenol, 4-bromo-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; (4-Bromo-2-hydroxyphenyl)boronic acid pinacol ester; 4-Bromo-2-hydroxyphenylboronic acid pinacol ester; 2-Hydroxy-5-bromophenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency for demanding synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to light and oxidation, prolonged exposure to air and light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.