Description

(1-(2-Cyanopropan-2-Yl)-1H-Pyrazol-4-Yl)Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate belonging to the class of protected boronic acid esters. This compound is a critical building block in modern synthetic chemistry, valued for its stability and reactivity in cross-coupling reactions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients. Its pinacol ester protection enhances handling characteristics while maintaining the necessary reactivity for key bond-forming steps.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl/heteroaryl halides and the boronic ester moiety, essential for constructing complex molecular architectures in drug discovery.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of potential active pharmaceutical ingredients (APIs), particularly those containing pyrazole and nitrile functional groups.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the pyrazole core is a common bioactive scaffold.
• Material Science Research: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its conjugated system.
• Chemical Biology & Probe Development: Useful for creating bioconjugates or molecular probes for studying biological processes, leveraging the boronic acid's potential for further functionalization.

Basic Information

Product Name	(1-(2-Cyanopropan-2-Yl)-1H-Pyrazol-4-Yl)Boronic Acid Pinacol Ester
CAS No.	2095779-29-4
Molecular Formula	C15H22BN3O2
Molecular Weight	287.17 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2-cyanopropan-2-yl)-1H-pyrazole; 1-(2-Cyano-2-propyl)-1H-pyrazole-4-boronic acid pinacol ester; 1-(2-Cyanopropan-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-(2-Cyanoisopropyl)-1H-pyrazole-4-boronic acid pinacol ester; 1-(1-Cyano-1-methylethyl)-1H-pyrazole-4-boronic acid pinacol ester; 4-Borono-1-(2-cyanopropan-2-yl)-1H-pyrazole pinacol ester; Pyrazole boronic ester derivative CAS 2095779-29-4
EINECS	Contact for details

Quality Control

Our (1-(2-Cyanopropan-2-Yl)-1H-Pyrazol-4-Yl)Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (argon or nitrogen) due to its moisture-sensitive and easily oxidized nature. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (H-NMR)	Conforms to structure
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.