Description

2H-Isoindole-2-Acetic Acid, 6-Bromo-1,3-Dihydro-α-Methyl-1-Oxo-, 1,1-Dimethylethyl Ester, (αr)- is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound is critical for enabling complex synthetic routes in modern drug discovery and development, particularly for targeted therapies. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) research.
• Organic Synthesis Reagent: Used in complex multi-step organic reactions, including cross-coupling and esterification processes, to construct intricate molecular architectures.
• Medicinal Chemistry Research: Serves as a crucial scaffold for structure-activity relationship (SAR) studies and the development of targeted small-molecule inhibitors.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic pathways for potential Active Pharmaceutical Ingredients (APIs).
• Chemical Reference Standard: Used as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	2H-Isoindole-2-Acetic Acid, 6-Bromo-1,3-Dihydro-α-Methyl-1-Oxo-, 1,1-Dimethylethyl Ester, (αr)-
CAS No.	2095633-67-1
Molecular Formula	C15H16BrNO3
Molecular Weight	338.20 g/mol
Synonyms	tert-Butyl (αR)-6-bromo-α-methyl-1-oxo-2,3-dihydro-1H-isoindole-2-acetate; (R)-tert-Butyl 2-(6-bromo-1-oxo-2,3-dihydro-1H-isoindol-2-yl)propanoate; (αR)-6-Bromo-1,3-dihydro-α-methyl-1-oxo-2H-isoindole-2-acetic Acid 1,1-Dimethylethyl Ester; (R)-6-Bromo-α-methyl-1-oxoisoindoline-2-acetic Acid tert-Butyl Ester; 2H-Isoindole-2-acetic acid, 6-bromo-1,3-dihydro-α-methyl-1-oxo-, 1,1-dimethylethyl ester, (αR)-; AR-2095633-67-1; BR-2095633-67-1
EINECS	Contact for details

Quality Control

Our 2H-Isoindole-2-Acetic Acid, 6-Bromo-1,3-Dihydro-α-Methyl-1-Oxo-, 1,1-Dimethylethyl Ester, (αr)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.