Description

tert-Butyl 5-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate is a high-purity, protected indole boronic ester building block designed for advanced pharmaceutical and agrochemical research. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. It is an essential intermediate for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), particularly in oncology and CNS therapeutic areas.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) research.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester partner for palladium-catalyzed coupling with aryl/heteroaryl halides to create biaryl structures.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides requiring complex heterocyclic cores.
• Material Science Research: Intermediate for creating organic electronic materials, such as OLEDs and semiconductors, where the indole-boronate moiety is incorporated.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for target identification and validation studies.
• Process Chemistry: Employed in route scouting and scale-up development for the commercial manufacturing of complex molecules.

Basic Information

Product Name	tert-Butyl 5-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole-1-Carboxylate
CAS No.	2095464-28-9
Molecular Formula	C19H25BFNO4
Molecular Weight	361.22 g/mol
Synonyms	1-Boc-5-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indole; 5-Fluoro-1H-indole-1-carboxylic acid, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester; tert-Butyl 5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate; 5-Fluoro-3-(pinacolatoboryl)-1H-indole-1-carboxylic acid tert-butyl ester; Boc-5-Fluoro-3-Bpin-indole; 2095464-28-9
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the stringent requirements for research and development applications. Certificates of Analysis (COA) with full analytical data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.