Description

4-Fluoro-6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzo[1,3]Dioxole is a high-value, synthetically versatile boronic ester derivative, serving as a critical building block in modern organic synthesis. Its primary value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone methodology for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise, scalable, and reliable synthetic intermediates for developing active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used to construct novel herbicide and pesticide molecules, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Material Science Research: Building block for creating organic electronic materials, such as ligands for OLEDs and charge-transport materials, where the benzo[1,3]dioxole moiety can influence optoelectronic properties.
• Chemical Biology & Probe Development: Employed in the synthesis of fluorinated molecular probes and tags for imaging and diagnostic applications.
• Cross-Coupling Reactions: A dedicated reagent for Suzuki-Miyaura cross-coupling with various aryl/heteroaryl halides, enabling the efficient synthesis of biaryl and heterobiaryl structures.
• Library Synthesis for Drug Discovery: Facilitates the rapid generation of diverse compound libraries in medicinal chemistry programs for high-throughput screening.

Basic Information

Product Name	4-Fluoro-6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzo[1,3]Dioxole
CAS No.	2092675-16-4
Molecular Formula	C13H16BFO4
Molecular Weight	266.08 g/mol
Synonyms	6-Fluoro-2,2-dimethylbenzo[d][1,3]dioxole-5-boronic acid pinacol ester; 5-Fluoro-2,2-dimethylbenzo[d][1,3]dioxole-6-boronic acid pinacol ester; 4-Fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-benzodioxole; 6-Fluoro-benzo[1,3]dioxol-5-ylboronic acid pinacol ester; Pinacol 6-Fluorobenzo[d][1,3]dioxol-5-ylboronate; 2092675-16-4
EINECS	Contact for details

Quality Control

Our 4-Fluoro-6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzo[1,3]Dioxole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when dispensing to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.