Description

2'-Bromo-5'-Chloro-4'-Fluoroacetophenone is a high-purity, multi-halogenated acetophenone derivative serving as a critical building block in advanced organic synthesis. This compound matters because its unique halogen substitution pattern provides distinct reactivity and selectivity, enabling the construction of complex molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and fungicides, leveraging its halogenated structure for enhanced bioactivity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and liquid crystals.
• Chemical Biology Probes: Utilized to develop molecular probes and tags for studying enzyme mechanisms and protein interactions.
• Cross-Coupling Reactions: Acts as an electrophilic partner in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl systems.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring specific halogenated aromatic ketones.

Basic Information

Product Name	2'-Bromo-5'-Chloro-4'-Fluoroacetophenone
CAS No.	2092325-31-8
Molecular Formula	C8H5BrClFO
Molecular Weight	251.48 g/mol
Synonyms	1-(2-Bromo-5-chloro-4-fluorophenyl)ethan-1-one; 2-Bromo-5-chloro-4-fluoroacetophenone; α-Bromo-5-chloro-4-fluoroacetophenone; 2'-Bromo-5'-chloro-4'-fluoroacetophenone; 1-Acetyl-2-bromo-5-chloro-4-fluorobenzene; Ethanone, 1-(2-bromo-5-chloro-4-fluorophenyl)-; 2-Br-5-Cl-4-F-acetophenone
EINECS	Contact for details

Quality Control

Every batch of 2'-Bromo-5'-Chloro-4'-Fluoroacetophenone is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards and customer-specific requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; ensure the container is kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.