Description

7-Nitro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-indole is a high-value, multi-functional indole derivative containing both a nitro group and a pinacol boronate ester. This compound matters as a critical synthetic intermediate, enabling advanced cross-coupling reactions like the Suzuki-Miyaura reaction for constructing complex heterocyclic scaffolds. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing novel drug candidates, agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex indole-based molecules for potential therapeutic agents.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester functional group enables efficient palladium-catalyzed coupling with aryl/heteroaryl halides for carbon-carbon bond formation.
• Agrochemical Research: Used in the development of novel pesticides and herbicides that leverage the indole core structure.
• Material Science: A precursor for creating organic electronic materials and functional polymers with specific optoelectronic properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Library Synthesis for Drug Discovery: Enables the rapid generation of diverse compound libraries for high-throughput screening in medicinal chemistry.

Basic Information

Item	Details
Product Name	7-Nitro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-indole
CAS No.	2091135-03-2
Molecular Formula	C21H23BN2O6S
Molecular Weight	442.29 g/mol
Synonyms	1H-Indole, 7-nitro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-[(4-methylphenyl)sulfonyl]-; 7-Nitro-1-tosyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 3-Borono-7-nitro-1-tosyl-1H-indole pinacol ester; 7-Nitro-1-(p-toluenesulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indole; 7-Nitro-3-borono-1-tosylindole pinacol ester; N-Tosyl-7-nitro-3-boronoindole pinacol ester; 7-Nitro-3-(pinacolatoboryl)-1-tosyl-1H-indole
EINECS	Contact for details

Quality Control

Our 7-Nitro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-indole is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.