Description

(R)-2,2,2-Trifluoro-1-(Oxetan-3-Yl)Ethan-1-Amine is a high-value, chiral amine building block featuring a trifluoromethyl group and an oxetane ring. This compound is critical for introducing stereochemical complexity and fluorine atoms into target molecules, which can dramatically alter their metabolic stability, lipophilicity, and binding affinity. It is primarily sought after by pharmaceutical and agrochemical research organizations for the synthesis of novel active ingredients, particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of small-molecule drugs, especially protease inhibitors and kinase inhibitors.
• Agrochemical Research: Used in the synthesis of advanced herbicides and pesticides where the fluorine moiety enhances biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands in asymmetric catalysis, enabling the synthesis of enantiomerically pure compounds.
• Material Science: Incorporated into specialty polymers and advanced materials to modify surface properties and chemical resistance.
• Fluorine Chemistry Studies: A valuable substrate for investigating structure-activity relationships (SAR) in fluorinated organic molecules.

Basic Information

Product Name	(R)-2,2,2-Trifluoro-1-(Oxetan-3-Yl)Ethan-1-Amine
CAS No.	2089671-21-4
Molecular Formula	C6H8F3NO
Molecular Weight	167.13 g/mol
Synonyms	(R)-2,2,2-Trifluoro-1-(oxetan-3-yl)ethanamine; (R)-1-(Oxetan-3-yl)-2,2,2-trifluoroethanamine; (R)-α-(Trifluoromethyl)oxetane-3-methanamine; (3R)-3-(1-Amino-2,2,2-trifluoroethyl)oxetane; (R)-3-(Aminomethyl)-3-(trifluoromethyl)oxetane; (R)-Oxetane-3-yl(trifluoromethyl)methylamine; (R)-TFMOA
EINECS	Contact for details

Quality Control

Our (R)-2,2,2-Trifluoro-1-(Oxetan-3-Yl)Ethan-1-Amine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC to ensure enantiomeric purity, NMR for structural confirmation, and GC/HPLC for chemical purity and impurity profiling. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and industry standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.