Description

2-Chloro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-6-(Trifluoromethyl)Pyridine is a high-value, multi-functional boronic ester derivative, serving as a critical synthetic intermediate. Its core value proposition lies in enabling efficient cross-coupling reactions, specifically Suzuki-Miyaura couplings, to construct complex heterocyclic scaffolds. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethylpyridine motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific halogenated pyridine structures.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials, ligands for catalysis, and liquid crystals.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group makes it an ideal partner for palladium-catalyzed coupling with aryl or heteroaryl halides, enabling rapid diversification of molecular libraries.
• Medicinal Chemistry & Drug Discovery: A versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Chemical Biology Probes: Used to develop labeled compounds and probes for studying biological pathways and target engagement.

Basic Information

Product Name	2-Chloro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-6-(Trifluoromethyl)Pyridine
CAS No.	2068737-11-9
Molecular Formula	C12H14BClF3NO2
Molecular Weight	305.51 g/mol
Synonyms	2-Chloro-6-(trifluoromethyl)pyridine-3-boronic acid pinacol ester; 2-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine; 3-Borono-2-chloro-6-(trifluoromethyl)pyridine, pinacol ester; (2-Chloro-6-(trifluoromethyl)pyridin-3-yl)boronic acid pinacol ester; 2-Chloro-3-boronic acid pinacol ester-6-(trifluoromethyl)pyridine; PINACOL 2-CHLORO-6-(TRIFLUOROMETHYL)PYRIDIN-3-YLBORONATE; CAS 2068737-11-9
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-6-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) and at temperatures between 2°C and 8°C for long-term stability. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.