Description

2-(5-Chloro-2-(Methylthio)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical intermediate in modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality building blocks for drug discovery, crop protection agents, and organic electronic materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing chlorinated, methylthio-substituted biaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific halogenated aromatic frameworks.
• Material Science Research: Serves as a precursor for creating organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) via cross-coupling polymerization or functionalization.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tags for studying biological processes, leveraging the boronate group's utility in bioconjugation.
• Academic & Process R&D: A valuable reagent for methodology development and scaling up synthetic routes in university and industrial R&D laboratories.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and libraries.

Basic Information

Product Name	2-(5-Chloro-2-(Methylthio)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2060541-00-4
Molecular Formula	C13H18BClO2S
Molecular Weight	284.61 g/mol
Synonyms	5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl methyl sulfide; (5-Chloro-2-(methylthio)phenyl)boronic acid pinacol ester; 2-(5-Chloro-2-(methylsulfanyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Chloro-2-methylthiophenylboronic acid pinacol ester; 2060541-00-4; B-(5-Chloro-2-(methylthio)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-(5-Chloro-2-(Methylthio)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when opening containers to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.