Description

4H-Pyrrolo[1,2-B]Pyrazole, 5,6-Dihydro-5,5-Dimethyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-purity boronic ester derivative, a crucial building block in modern synthetic chemistry. Its value lies in enabling efficient, selective cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This advanced intermediate is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, where the pyrrolopyrazole scaffold can impart specific biological activity.
• Material Science Research: Serves as a functional monomer or building block for creating advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and labeled compounds for biochemical assays and diagnostic research.
• Catalyst Ligand Synthesis: The structural framework can be utilized to develop novel ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: An essential raw material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke organic compounds for clients.

Basic Information

Item	Details
Product Name	4H-Pyrrolo[1,2-B]Pyrazole, 5,6-Dihydro-5,5-Dimethyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	2057507-59-0
Molecular Formula	C15H25BN2O2
Molecular Weight	276.19 g/mol
Synonyms	5,6-Dihydro-5,5-dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4H-pyrrolo[1,2-b]pyrazole; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydro-5,5-dimethyl-4H-pyrrolo[1,2-b]pyrazole; 5,5-Dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole; 4H-Pyrrolo[1,2-b]pyrazole-3-boronic acid, 5,6-dihydro-5,5-dimethyl-, pinacol ester; Pinacol 5,5-dimethyl-4,5,6,7-tetrahydropyrrolo[1,2-b]pyrazole-3-boronate
EINECS	Contact for details

Quality Control

Our 4H-Pyrrolo[1,2-B]Pyrazole boronic ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural integrity suitable for sensitive cross-coupling reactions. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0% (Area Percent)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.