Description

Acetamide, n-(1,1-Dimethylethyl)-2-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy]- is a high-purity, advanced pharmaceutical intermediate featuring a unique acetamide-phenoxy-boronate ester structure. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for carbon-carbon bond formation. It is an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those requiring biaryl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with targeted activity.
• Material Science Research: Serves as a monomer or functional unit in the creation of advanced polymers, OLED materials, and liquid crystals.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura couplings to introduce the phenoxy-acetamide moiety into larger molecular architectures.
• Chemical Biology & Proteomics: Can be employed as a tool compound or linker in the development of chemical probes and bioconjugates.
• Academic & R&D Laboratories: A valuable reagent for methodological development and exploratory synthesis in organic chemistry.

Basic Information

Product Name	Acetamide, n-(1,1-Dimethylethyl)-2-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy]-
CAS No.	2056919-55-0
Molecular Formula	C20H32BNO4
Molecular Weight	361.29 g/mol
Synonyms	2-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)-N-(tert-butyl)acetamide; N-tert-Butyl-2-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetamide; 3-(Pinacolboryl)phenoxy-N-tert-butylacetamide; tert-Butylcarbamoylmethyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl ether; Boronic acid, B-[3-[[[(1,1-dimethylethyl)amino]carbonyl]methoxy]phenyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester; 2056919-55-0; Acetamide, N-(1,1-dimethylethyl)-2-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]-
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Quality Control

Our Acetamide, n-(1,1-Dimethylethyl)-2-[3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy]- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.