Description

2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-6-(Trifluoromethyl)Phenol is a high-purity, advanced pharmaceutical intermediate and versatile synthetic building block. This compound is valued for its unique combination of a protected boronic ester moiety and a phenolic trifluoromethyl group, enabling critical carbon-carbon bond formation in complex molecule synthesis. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel active ingredients and functional molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key boronic ester reagent for constructing biaryl and heterobiaryl scaffolds prevalent in drug discovery.
• Pharmaceutical Intermediate: Synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS), oncology, and inflammatory diseases.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides leveraging the stability and reactivity of the boronate group.
• Material Science Research: Precursor for organic electronic materials, such as OLEDs and OFETs, where the trifluoromethylphenol unit can influence charge transport and stability.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis.
• Chemical Biology Probes: Enables the synthesis of tagged molecules for studying biological pathways and protein interactions.

Basic Information

Product Name	2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-6-(Trifluoromethyl)Phenol
CAS No.	2055742-98-6
Molecular Formula	C₁₃H₁₆BF₃O₃
Molecular Weight	288.07 g/mol
Synonyms	6-(Trifluoromethyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; 2-Hydroxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzotrifluoride; Pinacol [3-hydroxy-2-(trifluoromethyl)phenyl]boronate; 2-(Pinacolatoboryl)-6-(trifluoromethyl)phenol; 2-Borono-6-(trifluoromethyl)phenol pinacol ester; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)benzenol
EINECS	Contact for details

Quality Control

Every batch of 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-6-(Trifluoromethyl)Phenol is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.