Description

n-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]-[1,1'-Biphenyl]-4-Amine is a high-purity, advanced pharmaceutical intermediate and organic building block featuring a pinacol boronate ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for constructing complex biaryl systems. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and materials science sectors for the development of novel active ingredients and functional organic materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing biphenyl or extended conjugated systems.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for palladium-catalyzed carbon-carbon bond formation to create complex biaryl structures.
• Organic Light-Emitting Diodes (OLEDs): Used in the research and production of hole-transporting materials (HTMs) and emitters for display and lighting technologies.
• Agrochemical Synthesis: Intermediate in the creation of novel herbicides, fungicides, and insecticides with tailored properties.
• Material Science Research: Building block for organic semiconductors, conductive polymers, and metal-organic frameworks (MOFs).
• Ligand and Catalyst Development: Precursor for synthesizing specialized ligands used in homogeneous catalysis.

Basic Information

Product Name	n-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]-[1,1'-Biphenyl]-4-Amine
CAS No.	2055286-48-9
Molecular Formula	C24H26BNO2
Molecular Weight	371.28 g/mol
Synonyms	4'-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1'-biphenyl]-4-amine; [1,1'-Biphenyl]-4-amine, 4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 4-Amino-4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)biphenyl; N-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-[1,1'-biphenyl]-4-amine; 4-Biphenylamine boronic acid pinacol ester; (4'-Amino-[1,1'-biphenyl]-4-yl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our n-[4-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]-[1,1'-Biphenyl]-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance for critical synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.