Description

Hydroxy-Peg9-T-Butyl Ester is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a terminal hydroxyl group and a t-butyl ester protecting group. This bifunctional structure makes it a versatile and valuable building block for bioconjugation, polymer synthesis, and the creation of advanced drug delivery systems. It is particularly sought after by researchers and manufacturers in the pharmaceutical, biotechnology, and specialty chemical industries for developing prodrugs, PEGylated therapeutics, and functional hydrogels.

Application

• Pharmaceutical Linker & Prodrug Synthesis: Serves as a cleavable spacer or solubilizing component in antibody-drug conjugates (ADCs) and small molecule prodrugs.
• PEGylation Reagent: Used to modify proteins, peptides, and nanoparticles to enhance solubility, reduce immunogenicity, and prolong circulation half-life.
• Polymer Chemistry: Acts as a monomer or macroinitiator for synthesizing biodegradable and stimuli-responsive block copolymers.
• Surface Functionalization: Employed to create hydrophilic, non-fouling coatings on medical devices and diagnostic platforms.
• Cross-linking Agent: Utilized in the formation of hydrogels and polymer networks for controlled release applications.
• Intermediate for Specialty Chemicals: A key precursor for synthesizing more complex PEG-based surfactants, ligands, and functional materials.

Basic Information

Product Name	Hydroxy-Peg9-T-Butyl Ester
CAS No.	2055042-66-3
Molecular Formula	C23H46O12 (or based on exact PEG chain length)
Molecular Weight	~ 500-550 g/mol (Contact for exact value)
Synonyms	2-[2-[2-[2-[2-[2-[2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 2,2-dimethylpropanoate; 2,2-Dimethylpropanoic Acid PEG9 Ester; tert-Butyl-PEG9-alcohol; HO-PEG9-OtBu; α-Hydroxy-ω-t-butoxy-nonaethylene glycol; Poly(ethylene glycol) monomethyl ether 9-monomethyl ether t-butyl ester; 3,6,9,12,15,18,21,24,27-Nonaoxanonatriacontan-1-ol, 30-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our Hydroxy-Peg9-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets precise specifications for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C or as indicated on the label. Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
PEG Diol Content (HPLC)	≤ 3.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.