Description

4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Naphthalene-1-Carboxylic Acid Amide is a high-value, advanced pharmaceutical intermediate featuring a naphthalene core functionalized with a pinacol boronate ester and a primary amide group. This compound matters as a versatile building block in modern synthetic chemistry, enabling the construction of complex molecules through key cross-coupling reactions. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in drug discovery programs targeting various therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates via Suzuki-Miyaura cross-coupling reactions.
• Organic Synthesis Building Block: Used in medicinal chemistry for the late-stage functionalization and diversification of lead compounds.
• Agrochemical Research: Employed in the development of new active ingredients for crop protection products.
• Material Science: Potential monomer or precursor for the synthesis of organic electronic materials and polymers.
• Academic & Contract Research: Serves as a specialized reagent in university and CRO laboratories for method development and novel compound library synthesis.

Basic Information

Product Name	4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Naphthalene-1-Carboxylic Acid Amide
CAS No.	2054338-98-4
Molecular Formula	C₁₇H₂₀BNO₃
Molecular Weight	297.16 g/mol
Synonyms	1-Naphthamide, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-naphthamide; 4-Pinacolatoboryl-1-naphthamide; Naphthalene-1-carboxamide, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 4-Boronyl-1-naphthamide pinacol ester
EINECS	Contact for details

Quality Control

Our 4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Naphthalene-1-Carboxylic Acid Amide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with internal and regulatory standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.