Description

Chloro(4-Cyanophenyl){(R)-1-[(S)-2-(Bis(4-Fluorophenyl)Phosphinoferrocenyl]Ethyl(Di-T-Butylphosphine)}Nickel(II) is a highly specialized, chiral nickel(II) pincer complex designed for advanced catalytic applications. This compound matters because it offers exceptional stereoselectivity and activity as a pre-catalyst in cross-coupling and related transformations, enabling the synthesis of complex, optically active molecules. It is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise control over molecular architecture.

Application

• Asymmetric Catalysis: A key pre-catalyst for enantioselective cross-coupling reactions, such as Suzuki-Miyaura and Kumada couplings, to construct chiral biaryl and other stereogenic centers.
• Pharmaceutical Intermediate Synthesis: Enables the efficient, stereocontrolled construction of complex drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of novel, chiral pesticides and herbicides where specific stereochemistry is critical for bioactivity.
• Material Science: Potential catalyst for the synthesis of chiral polymers or organic electronic materials with tailored properties.
• Methodology Development: A valuable tool for academic and industrial researchers exploring new catalytic cycles and reaction mechanisms involving earth-abundant metals.
• Fine Chemical Production: Applicable in pilot-scale and small-volume production of high-value, optically pure specialty chemicals.

Basic Information

Product Name	Chloro(4-Cyanophenyl){(R)-1-[(S)-2-(Bis(4-Fluorophenyl)Phosphinoferrocenyl]Ethyl(Di-T-Butylphosphine)}Nickel(II)
CAS No.	2049086-37-3
Molecular Formula	C45H41ClF4FeNNiP2
Molecular Weight	867.80 g/mol
Synonyms	Nickel(II) Pincer Complex with Josiphos-type Ligand; Chiral Nickel Catalyst 2049086-37-3; (R,S)-Josiphos Nickel(II) Cyanophenyl Chloride Complex; (R)-1-[(S)-2-(Bis(4-Fluorophenyl)Phosphino)ferrocenyl]ethyl(di-tert-butyl)phosphine(4-cyanophenyl)chloronickel(II); Ni-Josiphos Catalyst Derivative; Asymmetric Nickel Pincer Catalyst; Chloro(4-cyanophenyl)nickel(II) Josiphos Complex
EINECS	Contact for details

Quality Control

Every batch of this advanced catalyst is synthesized and handled under strict inert atmosphere conditions to preserve its integrity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Purity and identity are confirmed via NMR (1H, 31P), HPLC, and elemental analysis. Certificates of Analysis (COA) detailing lot-specific data are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties of being easily oxidized (store under inert atmosphere) and hygroscopic (moisture-sensitive), this material must be stored under an inert gas (argon or nitrogen) in a sealed vial or Schlenk flask. Recommended long-term storage temperature is between 2°C and 8°C. Handle and open containers only in a controlled, moisture-free, and oxygen-free environment.

Specification

Item	Specification
Appearance	Orange to red-brown solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Chiral Purity	≥ 99% ee (by chiral HPLC or SFC)
Elemental Analysis (C, H, N)	Within ±0.4% of theoretical
Solubility	Soluble in common organic solvents (e.g., THF, DCM, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.