Description

Chloro(4-Cyanophenyl){(R)-1-[(S)-2-(Dicyclohexylphosphino)Ferrocenyl]Ethyl (Dicyclohexylphosphine)}Nickel(II) is a highly specialized, chiral nickel(II) complex featuring a ferrocenyl-based phosphine ligand, designed for advanced catalytic transformations. This compound is valued for its precise stereochemical control and unique electronic properties, making it a critical component in sophisticated synthetic methodologies. It is primarily sought by research institutions and industrial R&D departments focused on developing novel pharmaceuticals, agrochemicals, and high-performance materials through asymmetric synthesis.

Application

• Asymmetric Catalysis: A key catalyst for enantioselective cross-coupling reactions, including Suzuki-Miyaura and Negishi couplings, to construct chiral biaryl and other complex molecular frameworks.
• Pharmaceutical Intermediate Synthesis: Enables the production of single-enantiomer intermediates for active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Research: Used in the development of chiral pesticides and herbicides where specific stereochemistry is required for biological activity and environmental safety.
• Material Science: Facilitates the synthesis of chiral polymers and organic electronic materials with tailored optoelectronic properties.
• Methodology Development: Serves as a benchmark catalyst in academic and industrial laboratories for developing new catalytic protocols in organometallic chemistry.
• Fine Chemical Production: Applied in the pilot-scale manufacture of high-value, complex fine chemicals where traditional catalysts fail to provide the necessary selectivity.

Basic Information

Product Name	Chloro(4-Cyanophenyl){(R)-1-[(S)-2-(Dicyclohexylphosphino)Ferrocenyl]Ethyl (Dicyclohexylphosphine)}Nickel(II)
CAS No.	2049086-35-1
Molecular Formula	C41H48ClFeNPPNi
Molecular Weight	762.78 g/mol (approx.)
Synonyms	Nickel(II) Chloro(4-cyanophenyl)((R)-1-((S)-2-(dicyclohexylphosphino)ferrocenyl)ethyl)dicyclohexylphosphine; (R,S)-Josiphos Nickel(II) Chloride Cyanophenyl Complex; Chiral Josiphos Nickel Catalyst; (R)-1-[(S)-2-(Dicyclohexylphosphino)ferrocenyl]ethyl(dicyclohexylphosphine)(4-cyanophenyl)chloronickel(II); Asymmetric Nickel Josiphos Catalyst; Nickel(II) Complex with (R,S)-PPF-PCy2; Ferrocenylphosphine Nickel Catalyst; 2049086-35-1
EINECS	Contact for details

Quality Control

Every batch of our Chloro(4-Cyanophenyl){(R)-1-[(S)-2-(Dicyclohexylphosphino)Ferrocenyl]Ethyl (Dicyclohexylphosphine)}Nickel(II) is synthesized and handled under strict inert conditions to preserve its catalytic activity. We employ advanced analytical techniques, including NMR, HPLC, and elemental analysis, to verify identity, chiral purity, and chemical purity. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment, ensuring full traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to minimize oxidation and hydrolysis. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Orange to red-brown solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Chiral Purity (Chiral HPLC)	≥ 99% ee
Elemental Analysis	Within theoretical range
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.