Description

Chloro(4-Cyanophenyl)[(R)-1-[(S)-2-(Diphenylphosphino)Ferrocenyl]Ethylditertbutylphosphine]Nickel(II) is a sophisticated, chiral nickel(II) complex featuring a ferrocenyl-based Josiphos-type ligand, designed for high-performance asymmetric catalysis. This compound matters because it provides exceptional stereocontrol and activity in challenging cross-coupling and C-H functionalization reactions, enabling the synthesis of complex, enantiomerically pure molecules. It is a critical tool for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require robust and selective catalysts for constructing chiral centers.

Application

• Asymmetric Cross-Coupling Reactions: A premier catalyst for enantioselective Suzuki-Miyaura, Negishi, and Kumada couplings to form chiral biaryl and alkyl-aryl bonds.
• Pharmaceutical Intermediate Synthesis: Enables the efficient, stereoselective construction of key chiral scaffolds for active pharmaceutical ingredients (APIs).
• Agrochemical Product Development: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• C-H Bond Functionalization: Facilitates selective, asymmetric C-H activation for the direct introduction of functional groups into complex molecules.
• Polymer and Materials Science: Catalyst for the synthesis of chiral polymers and organic electronic materials with specific optical properties.
• Methodology Development in Academia: A valuable reagent for exploring new catalytic asymmetric transformations in university and institutional research labs.

Basic Information

Product Name	Chloro(4-Cyanophenyl)[(R)-1-[(S)-2-(Diphenylphosphino)Ferrocenyl]Ethylditertbutylphosphine]Nickel(II)
CAS No.	2049086-34-0
Molecular Formula	C45H44ClFeNPPNi
Molecular Weight	~ 810.0 g/mol
Synonyms	Nickel(II) (R)-1-[(S)-2-(Diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine chloro(4-cyanophenyl) complex; (R,S)-Josiphos Nickel(II) 4-Cyanophenyl Chloride Complex; Ni-Josiphos Catalyst Derivative; Chiral Nickel Ferrocenylphosphine Complex; Asymmetric Nickel Catalyst; (R)-1-[(S)-2-(Diphenylphosphino)ferrocenyl]ethyldi(tert-butyl)phosphine-(4-cyanophenyl)chloronickel(II); CAS 2049086-34-0.
EINECS	Contact for details

Quality Control

Every batch of this high-value catalyst is produced and tested under strict inert atmosphere conditions to prevent decomposition. Our quality assurance includes comprehensive analytical characterization to confirm identity, chiral purity, and catalytic activity. Certificates of Analysis (COA) are provided, detailing results from NMR, HPLC, and elemental analysis. We adhere to cGMP principles for traceability and documentation, ensuring reliability for critical process development and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C or as specified on the label. This compound is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or ambient light will degrade performance. Handle and open containers only in a controlled, oxygen-free environment.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline solid or powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Chiral Purity (Chiral HPLC)	≥ 99% ee
Elemental Analysis (C, H, N)	Within ± 0.4% of theoretical
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.