Description

3-Fluoroazetidine-1-Ethanamine CAS NO 2045189-35-1 is a high-value, functionalized azetidine building block featuring a primary amine linker. This compound is critical for medicinal chemistry and drug discovery, enabling the rapid synthesis of novel bioactive molecules with improved pharmacokinetic properties. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers for developing new therapeutic agents, particularly in oncology and CNS disorders.

Application

• Pharmaceutical Intermediate: A key synthon for constructing novel small molecule drug candidates, especially kinase inhibitors and GPCR modulators.
• Bio-conjugation & Linker Chemistry: The primary amine group facilitates its use as a versatile linker for attaching fluorinated azetidine motifs to antibodies, peptides, or other biomolecules (ADC development).
• Agrochemical Research: Serves as a building block for designing new generation herbicides and pesticides with enhanced activity and selectivity.
• Material Science: Used in the synthesis of advanced polymers and functional materials where the fluorinated heterocycle imparts specific chemical resistance or surface properties.
• Chemical Biology Probes: Employed in the development of fluorescent or affinity-based probes to study enzyme function and biological pathways.

Basic Information

Product Name	3-Fluoroazetidine-1-Ethanamine
CAS No.	2045189-35-1
Molecular Formula	C5H11FN2
Molecular Weight	118.15 g/mol
Synonyms	2-(3-Fluoroazetidin-1-yl)ethan-1-amine; 1-(2-Aminoethyl)-3-fluoroazetidine; 3-Fluoro-1-(2-aminoethyl)azetidine; N-(2-Aminoethyl)-3-fluoroazetidine; 3-Fluoroazetidine ethylamine; Azetidine, 3-fluoro-1-(2-aminoethyl)-; FC-1238 (Potential research code)
EINECS	Contact for details

Quality Control

Our 3-Fluoroazetidine-1-Ethanamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Assay (Titration)	95.0 - 105.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.