Description

4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Naphthol is a high-purity boronic ester derivative of 2-naphthol, serving as a critical synthetic intermediate in modern organic chemistry. Its value lies in providing a protected boronic acid functionality that is stable to purification and storage, enabling precise cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable building blocks for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require naphthalene-based structures.
• Organic Light-Emitting Diodes (OLEDs): Serves as a precursor for creating complex organic semiconductors and charge-transport materials used in display technologies.
• Ligand and Catalyst Development: Utilized to synthesize novel bidentate or polydentate ligands for transition metal catalysis.
• Polymer and Material Science: Acts as a monomer or functionalization agent in the production of specialty polymers with tailored properties.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D in synthetic methodology and medicinal chemistry.

Basic Information

Item	Details
Product Name	4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Naphthol
CAS No.	2043962-01-0
Molecular Formula	C16H21BO3
Molecular Weight	272.15 g/mol
Synonyms	2-Naphthol-4-boronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-ol; 2-Hydroxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalene; 4-(Pinacolatoboryl)-2-naphthol; 4-Borono-2-naphthol pinacol ester; 4-(2-Naphthyl)boronic acid pinacol ester (isomer specific); Naphthalen-2-ol, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Our 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Naphthol is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports applications requiring high standards, including cGMP development and research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.