Description

Methyl 3-Fluoro-5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine-2-Carboxylate is a high-value, multi-functional chemical building block designed for advanced synthetic applications. Its core value lies in the strategic combination of a pyridine carboxylate ester, a fluorine substituent, and a protected boronic ester (pinacol boronate), enabling precise cross-coupling reactions and further derivatization. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate in the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block in Suzuki-Miyaura cross-coupling reactions for constructing complex biaryl structures found in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require fluorinated heterocyclic cores.
• Material Science Research: Serves as a precursor for creating functionalized ligands, organic semiconductors, and metal-organic frameworks (MOFs).
• Chemical Biology & Probe Development: Utilized in synthesizing fluorinated molecular probes and tags for imaging and diagnostic applications.
• Process Chemistry & Scale-Up: Provides a reliable, high-purity starting material for optimizing synthetic routes from laboratory to pilot plant scale.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules.

Basic Information

Product Name	Methyl 3-Fluoro-5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine-2-Carboxylate
CAS No.	2043770-91-6
Molecular Formula	C13H17BFNO4
Molecular Weight	281.09 g/mol
Synonyms	Methyl 3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate; 3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinic acid methyl ester; 2-Pyridinecarboxylic acid, 3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; 3-Fluoro-5-(pinacolboryl)picolinic acid methyl ester; Methyl 3-Fluoro-5-(pinacolatoboron)picolinate; 5-Boronic acid, 3-fluoro-2-(methoxycarbonyl)pyridine, pinacol ester; CAS 2043770-91-6
EINECS	Contact for details

Quality Control

Every batch of Methyl 3-Fluoro-5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine-2-Carboxylate is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize moisture uptake. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.