Description

1,3-Dimethyl-5-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxa-Borolan-2-Yl)-Benzyl]-Pyrimidine-2,4,6-Trione is a high-value, organoboron-containing heterocyclic compound that serves as a critical synthetic intermediate. Its core value lies in the versatile boronic ester functional group, which enables efficient cross-coupling reactions for constructing complex molecular architectures. This advanced building block is primarily needed by pharmaceutical R&D and fine chemical synthesis teams developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used to construct complex molecules for developing new-generation pesticides and herbicides with enhanced efficacy.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as OLED emitters and charge transport layers.
• Chemical Biology Probes: Employed in the synthesis of bioconjugates and probes for studying biological pathways and protein interactions.
• Catalyst Ligand Development: The pyrimidine-trione core can be functionalized to create novel ligands for transition metal catalysis.
• Academic & Contract Research: Essential reagent for methodological development in synthetic organic chemistry laboratories worldwide.

Basic Information

Product Name	1,3-Dimethyl-5-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxa-Borolan-2-Yl)-Benzyl]-Pyrimidine-2,4,6-Trione
CAS No.	2027543-00-4
Molecular Formula	C19H25BN2O5
Molecular Weight	372.23 g/mol
Synonyms	5-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione; 1,3-Dimethyl-5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)barbituric acid; 5-(4-(Pinacolatoboryl)benzyl)-1,3-dimethylbarbituric acid; 1,3-Dimethyl-5-(4-(pinacolatoboryl)benzyl)pyrimidine-2,4,6(1H,3H,5H)-trione; Barbituric acid boronic ester derivative; CAS 2027543-00-4
EINECS	Contact for details

Quality Control

Our 1,3-Dimethyl-5-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxa-Borolan-2-Yl)-Benzyl]-Pyrimidine-2,4,6-Trione is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) with full traceability are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.