Description

2-(4-Chloro-3-Cyclopropylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a crucial advanced intermediate in modern synthetic chemistry. Its value lies in enabling efficient and selective carbon-carbon bond formation, a cornerstone reaction for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries, where it serves as a key building block for active ingredients and functional materials. The CAS number for this compound is 2020084-22-2.

Application

This versatile boronic ester is primarily employed in Suzuki-Miyaura cross-coupling reactions, a Nobel Prize-winning methodology. Its applications are critical in several high-value industrial sectors:

• Pharmaceutical Intermediates: Synthesis of complex drug candidates, especially those containing biaryl or heterobiaryl motifs common in oncology, CNS, and antiviral therapies.
• Agrochemical Synthesis: Construction of novel active ingredients for herbicides, fungicides, and insecticides requiring specific chlorinated and cyclopropyl-substituted structures.
• Material Science & OLED Development: Building block for creating organic semiconductors, charge-transport materials, and light-emitting molecules used in electronic displays.
• Ligand & Catalyst Preparation: Precursor for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology & Probe Development: Used to create molecular probes and tools for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses serving the life sciences industry.

Basic Information

Item	Details
Product Name	2-(4-Chloro-3-Cyclopropylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2020084-22-2
Molecular Formula	C15H20BClO2
Molecular Weight	278.58 g/mol
Synonyms	4-Chloro-3-cyclopropylbenzeneboronic acid pinacol ester; (4-Chloro-3-cyclopropylphenyl)boronic acid pinacol ester; (4-Chloro-3-cyclopropylphenyl)pinacolboronate; 2-(4-Chloro-3-cyclopropylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Chloro-3-cyclopropylphenylboronic acid pinacol ester; Pinacol (4-chloro-3-cyclopropylphenyl)boronate; B-(4-Chloro-3-cyclopropylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our production of 2-(4-Chloro-3-Cyclopropylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, which include data from NMR (1H, 13C, 11B), HPLC, and GC analysis. Our quality systems are designed to meet the exacting standards required for pharmaceutical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature is 2-8°C for optimal stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Purity (GC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.