Description

Aminomethylboronic Acid Pinacol Ester Hydrochloride is a protected boronic acid derivative, a crucial building block in modern synthetic chemistry. Its value lies in its stability and reactivity, serving as a key intermediate for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on protease inhibitors and other bioactive molecules that incorporate boron functionality.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of boronic acid-based active pharmaceutical ingredients (APIs), especially protease inhibitors.
• Medicinal Chemistry Research: Used extensively in drug discovery programs for the development of novel therapeutic agents targeting enzymes like proteasomes and serine hydrolases.
• Suzuki-Miyaura Cross-Coupling: Serves as a stable, protected boronic ester reagent for forming carbon-carbon bonds, a fundamental reaction in constructing complex organic frameworks.
• Peptidomimetic Synthesis: Employed in the creation of peptide analogs where the boronic acid moiety acts as a transition-state mimic for enzyme inhibition.
• Bioconjugation and Probe Development: Utilized in the design and synthesis of chemical probes and bioconjugates for biochemical and diagnostic applications.
• Process Chemistry & Scale-Up: Provides a reliable and scalable intermediate for the GMP manufacturing of clinical trial materials and commercial drugs.

Basic Information

Product Name	Aminomethylboronic Acid Pinacol Ester Hydrochloride
CAS No.	298689-75-5
Molecular Formula	C9H19BClNO2
Molecular Weight	219.52 g/mol
Synonyms	(Aminomethyl)boronic Acid Pinacol Ester Hydrochloride; B-(Aminomethyl)boronic Acid Pinacol Ester Hydrochloride; 1-Amino-2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)ethane Hydrochloride; 2-(Aminomethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Hydrochloride; Pinanediol Ester of (Aminomethyl)boronic Acid Hydrochloride (common alternative); N-Boc Protected Aminomethylboronic Acid Pinacol Ester (related precursor); Bortezomib Intermediate
EINECS	Contact for details

Quality Control

Our Aminomethylboronic Acid Pinacol Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with full specification data are provided to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, low-humidity environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.