Description

Hydroxy-Peg6-Ch2Co2Tbu is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a terminal hydroxyl group and a tert-butyl ester-protected carboxylic acid. This bifunctional linker is engineered to provide controlled conjugation and solubility enhancement in advanced chemical synthesis. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and bioconjugation sectors, enabling the development of prodrugs, peptide modifications, and sophisticated drug delivery systems.

Application

• Pharmaceutical Intermediate: Serves as a key building block for the synthesis of antibody-drug conjugates (ADCs) and targeted therapeutics.
• Prodrug Synthesis: Utilized to create water-soluble prodrugs through its cleavable ester linkage, improving drug bioavailability.
• Peptide & Protein Modification: Enables site-specific PEGylation to enhance the stability, solubility, and circulation half-life of bioactive peptides and proteins.
• Polymer Chemistry: Acts as a functional monomer or cross-linker for creating advanced hydrogels and biocompatible polymers with tailored properties.
• Bioconjugation Reagent: Facilitates the covalent attachment of drugs, dyes, or other molecules to targeting ligands like antibodies or peptides.
• Material Science: Used in surface functionalization to create non-fouling or bioactive coatings for medical devices and diagnostics.

Basic Information

Product Name	Hydroxy-Peg6-Ch2Co2Tbu
CAS No.	297162-47-1
Molecular Formula	C25H50O11
Molecular Weight	526.66 g/mol
Synonyms	2-[2-[2-[2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid tert-butyl ester; 1-Hydroxy-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid tert-butyl ester; HO-PEG6-CH2COOtBu; tert-Butyl 2,5,8,11,14,17,20-heptaoxadocosanoate; PEG6 Acid tert-Butyl Ester; 15-Hydroxy-4,7,10,13-tetraoxapentadecan-1-oic acid tert-butyl ester (common naming variant); α-Hydro-ω-carboxy(tert-butyl ester) hexaethylene glycol
EINECS	Contact for details

Quality Control

Our Hydroxy-Peg6-Ch2Co2Tbu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP manufacturing. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines for pharmaceutical intermediates to support our global clientele in meeting their regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This material is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, seal under argon or nitrogen. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.