Description

2-Bromo-3,4,5,6-Tetrafluorobenzylchloride is a highly functionalized halogenated benzyl building block, crucial for introducing a reactive benzylic chloride handle into complex molecular architectures. Its value lies in enabling precise synthetic modifications in advanced chemical synthesis, where the combination of bromine, fluorine substituents, and the chloromethyl group offers unique reactivity and selectivity. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in fluorinated drug candidates.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and pesticides where the fluorinated aromatic core enhances biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in catalysis and material science.
• Functional Material Production: Employed in the manufacture of liquid crystals, organic semiconductors, and other advanced electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it a valuable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille).
• Derivatization for Analytical Standards: Used to prepare reference compounds and internal standards for analytical testing.

Basic Information

Product Name	2-Bromo-3,4,5,6-Tetrafluorobenzylchloride
CAS No.	292621-50-2
Molecular Formula	C7H2BrClF4
Molecular Weight	277.44 g/mol
Synonyms	1-(Bromomethyl)-2,3,4,5-tetrafluoro-6-chlorobenzene; (2-Bromo-3,4,5,6-tetrafluorophenyl)methyl chloride; Benzene, 1-(bromomethyl)-2,3,4,5-tetrafluoro-6-chloro-; 2-Bromo-3,4,5,6-tetrafluorobenzyl chloride; α-Bromo-2,3,4,5-tetrafluoro-6-chlorotoluene
EINECS	Contact for details

Quality Control

Our 2-Bromo-3,4,5,6-Tetrafluorobenzylchloride is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality systems are designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.