Description

(2S,3S)-3-Amino-1,1,1-Trifluoro-4-Methylpentan-2-Ol(Wxfc0747) CAS NO 291778-50-2 is a high-purity, chiral amino alcohol building block characterized by its trifluoromethyl group and defined stereochemistry. This compound is of significant value in pharmaceutical and agrochemical research for introducing fluorine atoms and chiral centers into target molecules, which can dramatically alter their metabolic stability, bioavailability, and binding affinity. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and advanced material sectors for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of fluorinated active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced, fluorinated pesticides and herbicides, where the fluorine atoms enhance lipophilicity and environmental stability.
• Catalyst and Ligand Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to achieve high enantioselectivity.
• Peptidomimetics Research: Incorporated into peptide analogs to improve metabolic resistance and membrane permeability for therapeutic applications.
• Material Science: Potential building block for specialty polymers and advanced organic frameworks that require specific stereochemistry and fluorine content.
• Chemical Biology Probes: Utilized in the design of molecular probes and inhibitors for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	(2S,3S)-3-Amino-1,1,1-Trifluoro-4-Methylpentan-2-Ol (Wxfc0747)
CAS No.	291778-50-2
Molecular Formula	C7H12F3NO
Molecular Weight	183.17 g/mol
Synonyms	(2S,3S)-3-Amino-1,1,1-trifluoro-4-methylpentan-2-ol; (2S,3S)-3-Amino-4-methyl-1,1,1-trifluoropentan-2-ol; 3-Amino-1,1,1-trifluoro-4-methylpentan-2-ol (stereoisomer); Wxfc0747; (3S)-3-Amino-1,1,1-trifluoro-4-methylpentan-2-ol; (2S,3S)-3-Amino-4-methyl-1,1,1-trifluoro-2-pentanol; Fluorinated Chiral Amino Alcohol; 291778-50-2
EINECS	Contact for details

Quality Control

Our (2S,3S)-3-Amino-1,1,1-Trifluoro-4-Methylpentan-2-Ol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC, NMR, and MS, to ensure high chemical and enantiomeric purity suitable for demanding R&D and scale-up applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.