Description

Bicyclo[2.2.1]Heptane-1-Carbonyl Fluoride, 2,2-Difluoro-7,7-Dimethyl-, (1R,4R)- (9Ci) is a high-purity, stereochemically defined fluorinated building block essential for advanced organic synthesis. Its value lies in the unique reactivity of the carbonyl fluoride group and the rigid, chiral bicyclic framework, enabling the precise introduction of fluorinated motifs into complex molecular architectures. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of fluorinated drug candidates, particularly in protease inhibitors and CNS-active molecules.
• Agrochemical Synthesis: Used to construct fluorinated analogs of pesticides and herbicides, leveraging fluorine's ability to enhance metabolic stability and bioavailability.
• Advanced Material Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers with tailored thermal and chemical resistance.
• Fluorination Reagent: Acts as a source of the acyl fluoride functional group for efficient amide and ester bond formation under mild conditions.
• Asymmetric Catalysis Research: Employed as a well-defined, chiral substrate for testing and developing new catalytic methodologies.
• Ligand and Catalyst Development: The rigid norbornane skeleton makes it a valuable scaffold for constructing novel chiral ligands and organocatalysts.

Basic Information

Item	Detail
Product Name	Bicyclo[2.2.1]Heptane-1-Carbonyl Fluoride, 2,2-Difluoro-7,7-Dimethyl-, (1R,4R)- (9Ci)
CAS No.	289722-44-7
Molecular Formula	C10H12F3O
Molecular Weight	196.20 g/mol
Synonyms	(1R,4R)-2,2-Difluoro-7,7-dimethylbicyclo[2.2.1]heptane-1-carbonyl fluoride; (1R,4R)-7,7-Dimethyl-2,2-difluoronorbornane-1-carbonyl fluoride; endo,exo-2,2-Difluoro-7,7-dimethylnorbornane-1-carbonyl fluoride; Fluorinated Norbornane Carbonyl Fluoride; Difluorodimethylnorbornanecarbonyl Fluoride
EINECS	Contact for details

Quality Control

Every batch of Bicyclo[2.2.1]Heptane-1-Carbonyl Fluoride, 2,2-Difluoro-7,7-Dimethyl-, (1R,4R)- (9Ci) is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure compliance with exacting purity and stereochemical integrity standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after initial opening to prevent hydrolysis. Keep away from strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.