Description

Bicyclo[2.2.1]Heptane-2-Carbonyl Fluoride, 4,7,7-Trimethyl-3-Oxo-, (1R,4R)- (9Ci) is a high-purity, stereochemically defined chiral building block featuring a reactive carbonyl fluoride group. This compound is valued for its role as a key intermediate in advanced organic synthesis, particularly in the development of pharmaceuticals and agrochemicals where precise molecular architecture is critical. It is essential for research and production chemists in fine chemical, pharmaceutical, and agrochemical industries seeking to introduce fluorinated or functionalized bicyclic frameworks into target molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially those containing complex, rigid bicyclic structures.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that leverage its unique steric and electronic properties.
• Advanced Material Science: Serves as a precursor for specialty polymers and liquid crystals where the bicyclo[2.2.1]heptane (norbornane) skeleton imparts thermal stability and rigidity.
• Fluorination Chemistry: The carbonyl fluoride moiety acts as a versatile fluorinating agent or a handle for further functional group transformations in complex molecule synthesis.
• Asymmetric Catalysis Ligand Synthesis: Used to construct sophisticated chiral ligands for asymmetric hydrogenation and other catalytic processes.
• Academic & R&D: A valuable tool for methodological studies in organic chemistry, including cycloaddition reactions and stereoselective synthesis.

Basic Information

Product Name	Bicyclo[2.2.1]Heptane-2-Carbonyl Fluoride, 4,7,7-Trimethyl-3-Oxo-, (1R,4R)- (9Ci)
CAS No.	289722-40-3
Molecular Formula	C11H15FO2
Molecular Weight	198.23 g/mol
Synonyms	(1R,4R)-4,7,7-Trimethyl-3-oxobicyclo[2.2.1]heptane-2-carbonyl fluoride; (1R,4R)-3-Oxo-4,7,7-trimethylbicyclo[2.2.1]heptane-2-carbonyl fluoride; endo-(1R)-4,7,7-Trimethyl-3-oxobicyclo[2.2.1]heptane-2-carbonyl fluoride; (1R,4R)-Camphor-2-carbonyl fluoride; 2-Carbonyl fluoride-4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane, (1R,4R)-; Fluorocarbonyl derivative of (1R,4R)-camphor
EINECS	Contact for details

Quality Control

Our Bicyclo[2.2.1]Heptane-2-Carbonyl Fluoride, 4,7,7-Trimethyl-3-Oxo-, (1R,4R)- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure high chemical and isomeric purity suitable for sensitive synthetic applications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opened to prevent hydrolysis of the reactive carbonyl fluoride group. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (1R,4R)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.