Description

1-Bromo-2-(Bromomethyl)-4-Iodobenzene, also known as Alpha,2-Dibromo-5-Iodotoluene, is a high-value, multi-halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine, bromomethyl, and iodine substituents on a benzene ring, makes it a versatile and reactive intermediate for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications in cross-coupling reactions and as a precursor to specialized ligands and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing complex, halogen-substituted aromatic cores via Suzuki, Stille, or other metal-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the introduction of specific halogen patterns is critical for bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for the preparation of specialized phosphine or N-heterocyclic carbene (NHC) ligands used in homogeneous catalysis.
• Materials Science Research: Employed in the synthesis of organic electronic materials, such as organic light-emitting diodes (OLEDs) or semiconductors, where halogenated aromatics tune electronic properties.
• Chemical Biology Probes: Utilized as a scaffold for creating tagged molecules or photoaffinity labels for studying biological systems and protein interactions.
• Custom Synthesis and Contract Research: A valuable reagent for custom synthesis houses and CROs (Contract Research Organizations) working on client-specific molecular targets.

Basic Information

Product Name	1-Bromo-2-(Bromomethyl)-4-Iodobenzene
CAS No.	289617-98-7
Molecular Formula	C7H5Br2I
Molecular Weight	375.83 g/mol
Synonyms	Alpha,2-Dibromo-5-Iodotoluene; 2-Bromomethyl-1-bromo-4-iodobenzene; 1-Bromo-2-(bromomethyl)-4-iodo-benzene; 4-Iodo-1,2-bis(bromomethyl)benzene (isomer); Benzene, 1-bromo-2-(bromomethyl)-4-iodo-; Toluene, α,2-dibromo-5-iodo-; 5-Iodo-α,2-dibromotoluene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-(Bromomethyl)-4-Iodobenzene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry for comprehensive characterization. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be incompatible with strong bases and certain organic solvents. Keep away from heat and ignition sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.