Description

(S,S)-3,4,5-Trifluorophenyl-Nas Bromide is a high-purity, chiral organofluorine building block essential for advanced pharmaceutical and agrochemical synthesis. Its value lies in the precise introduction of a trifluoromethylphenyl moiety with defined stereochemistry, enabling the development of novel bioactive compounds with enhanced metabolic stability and binding affinity. This intermediate is critically needed by R&D and process chemistry teams in the pharmaceutical, agrochemical, and specialty materials sectors for constructing complex molecular architectures.

Application

• Key chiral intermediate in the synthesis of novel pharmaceutical active ingredients (APIs), particularly for central nervous system (CNS) and anti-infective drugs.
• Building block for agrochemicals, including herbicides and fungicides, where the fluorine atoms improve lipophilicity and environmental stability.
• Precursor in materials science for the development of liquid crystals and advanced polymers with specific optical or electronic properties.
• Versatile reagent in asymmetric catalysis and medicinal chemistry research for structure-activity relationship (SAR) studies.
• Intermediate for PET (Positron Emission Tomography) tracer development, utilizing fluorine-18 labeling.
• Used in the synthesis of ligands for metal-organic frameworks (MOFs) and catalytic complexes.

Basic Information

Product Name	(S,S)-3,4,5-Trifluorophenyl-Nas Bromide
CAS No.	287384-12-7
Molecular Formula	C9H6BrF3
Molecular Weight	251.04 g/mol
Synonyms	1-Bromo-3,4,5-trifluorobenzene, (S,S)-isomer; (S,S)-1-Bromo-3,4,5-trifluorobenzene; 3,4,5-Trifluorophenyl bromide, chiral; (S,S)-3,4,5-Trifluorobromobenzene; (1S,1'S)-3,4,5-Trifluorophenyl bromide; Bromotrifluorobenzene, chiral specific; CAS 287384-12-7
EINECS	Contact for details

Quality Control

Every batch of (S,S)-3,4,5-Trifluorophenyl-Nas Bromide is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.