Description

2-Pyrrolidinecarboxaldehyde, 4-Nitro-, (2R,4S)-Rel- (9Ci) is a high-purity, stereochemically defined chiral building block. This compound is a critical intermediate in the synthesis of complex pharmaceutical molecules, particularly those targeting neurological and cardiovascular pathways. It is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require enantiomerically pure intermediates for asymmetric synthesis and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially protease inhibitors and other enzyme-targeted therapies.
• Asymmetric Catalysis Research: Used as a precursor or ligand in the development of new chiral catalysts for stereoselective reactions.
• Agrochemical Synthesis: Serves as a building block for creating enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Employed in the custom synthesis of complex, high-value specialty chemicals for advanced material science.
• Academic & R&D Laboratories: Utilized in medicinal chemistry programs and methodological studies for constructing nitrogen-containing heterocycles.

Basic Information

Product Name	2-Pyrrolidinecarboxaldehyde, 4-Nitro-, (2R,4S)-Rel- (9Ci)
CAS No.	286392-25-4
Molecular Formula	C5H8N2O3
Molecular Weight	144.13 g/mol
Synonyms	(2R,4S)-4-Nitro-2-pyrrolidinecarboxaldehyde; rel-(2R,4S)-4-Nitroproline aldehyde; 4-Nitro-L-prolinal (relative configuration); (R,S)-4-Nitropyrrolidine-2-carboxaldehyde; 4-Nitroproline Aldehyde; 286392-25-4; 2-Pyrrolidinecarboxaldehyde, 4-nitro-, (2R,4S)-rel-
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and purity for sensitive synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing chiral purity, chemical purity, and impurity profiles. We operate under a cGMP-compliant quality management system, and specifications can be tailored to meet the rigorous demands of pharmaceutical development (e.g., ICH guidelines).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). Keep the container tightly sealed under an inert atmosphere if prolonged storage is required to maintain optimal purity.

Specification

Item	Specification
Appearance	Yellow to light brown solid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.