Description

4'-Chloro-3'-Methyl-2,2,2-Trifluoroacetophenone is a high-value trifluoromethylated aromatic ketone, a versatile and critical building block in advanced organic synthesis. Its molecular structure, featuring both chloro and methyl substituents on the aromatic ring alongside a reactive trifluoroacetyl group, makes it indispensable for introducing the metabolically stable trifluoromethyl moiety into target molecules. This compound is primarily sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the trifluoromethyl group to enhance metabolic stability, lipophilicity, and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves efficacy and environmental profile.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials with unique properties.
• Fluorine Chemistry Studies: An important reagent in academic and industrial research focused on exploring new fluorination methodologies and reaction pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Item	Detail
Product Name	4'-Chloro-3'-Methyl-2,2,2-Trifluoroacetophenone
CAS No.	286017-71-8
Molecular Formula	C9H6ClF3O
Molecular Weight	222.59 g/mol
Synonyms	1-(4-Chloro-3-methylphenyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(4-chloro-3-methylphenyl)ethanone; 4-Chloro-3-methyl-α,α,α-trifluoroacetophenone; 4-Chloro-3-methyl-2,2,2-trifluoroacetophenone; 4-Chloro-3-methyltrifluoroacetophenone; 4'-Chloro-3'-methyl-α,α,α-trifluoroacetophenone
EINECS	Contact for details

Quality Control

Every batch of 4'-Chloro-3'-Methyl-2,2,2-Trifluoroacetophenone is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure it meets the high standards required for synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment ensures reliable performance and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.