Description

Isoquinoline, 1,2,3,4-Tetrahydro-2-(Trifluoroacetyl)-7-(Trifluoromethyl)- is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, which incorporates both a tetrahydroisoquinoline scaffold and multiple trifluoromethyl/trifluoroacetyl groups, enabling precise modulation of lipophilicity, metabolic stability, and binding affinity in target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used to develop novel herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and environmental persistence.
• Material Science: Serves as a building block for advanced organic electronic materials, such as charge-transport layers or fluorinated polymers.
• Ligand & Catalyst Development: The nitrogen-containing heterocycle can be functionalized to create novel chiral ligands or organocatalysts for asymmetric synthesis.
• Fluorine Chemistry Research: An important substrate for studying the introduction and reactivity of polyfluorinated groups in complex molecular systems.
• Chemical Biology Probes: Utilized in the design of molecular probes and tags for studying biological processes due to its distinct spectroscopic signature.

Basic Information

Product Name	Isoquinoline, 1,2,3,4-Tetrahydro-2-(Trifluoroacetyl)-7-(Trifluoromethyl)-
CAS No.	284027-34-5
Molecular Formula	C₁₃H₁₁F₆NO
Molecular Weight	311.23 g/mol
Synonyms	7-(Trifluoromethyl)-1,2,3,4-tetrahydro-2-(trifluoroacetyl)isoquinoline; 2-(Trifluoroacetyl)-7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-7-(trifluoromethyl)-2-(2,2,2-trifluoroacetyl)isoquinoline; 7-Trifluoromethyl-1,2,3,4-tetrahydro-2-trifluoroacetylisoquinoline; TFATMIQ; CAS 284027-34-5
EINECS	Contact for details

Quality Control

Our Isoquinoline, 1,2,3,4-Tetrahydro-2-(Trifluoroacetyl)-7-(Trifluoromethyl)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as assay (HPLC), impurity profile, and physical characteristics. Our quality commitment supports compliance with cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.